一、个人信息:
姓名: 李兆栋;
出生日期: 1986/01/06;
籍贯: 山东省临沂市平邑县
二、联系方式:
E-mail: scaulizhaodong@scau.edu.cn;
三、个人简述(300字内)
李兆栋,博士,教授,博士生导师,2020年入选国家海外高层次人才引进计划(青年项目)。主持国家自然科学基金1项,省、厅级项目3余项。在化学顶级期刊JACS, Angew, Nat. Commun.等发表学术论文30余篇。
四、教育背景(依次介绍博士、硕士、本科)
2017.10 – 2018.09: 瑞士洛桑联邦理工大学应用化学研究所,博士后,导师:Prof. Jieping Zhu;
2014.09 – 2017.09: 瑞士苏黎世大学化学系,博士后,导师:Prof. Cristina Nevado;
2009.09 – 2014.07: 中国科学院上海有机化学研究所,硕博连读,获理学博士学位;
导师:李超忠研究员;
2005.09 – 2009.07:西南大学化学化工学院化学系,本科,获理学学士学位;
五、工作经历(主要工作简历+主要学术兼职)
2018年10月至今,best365网页版登录官网。
六、科研方向
(1)导向合成的自由基反应方法学研究。将自由基独特反应性与过渡金属催化相结合,发展环境友好的有机合成新反应。
(2)自由基反应在天然产物全合成中的应用。应用自由基偶联、环合、脱羧官能团化等反应,实现结构复杂天然产物特别是生物碱类分子合成中的关键化学转化和骨架构筑。
(3)关键药物中间体及新型农药的创制。运用新方法及设计新路线,开发具有竞争力的药物中间体新路线;在此基础上,开发新农药。
七、代表性科研论著
发表论文
1. Remote C(sp3)-H Functionalization Enabled by Copper-Catalyzed Cross Coupling of Oxime Esters with Terminal Alkynes: Synthesis of γ-Alkynyl Nitriles and Ketones.
Zhaodong Li,+ Rubén O. Torres-Ochoa,+ Qian Wang, Jieping Zhu*; Nat. Commun. 2020, 11, 403.
2. Copper-Catalyzed Arylation of Remote C(sp3)-H Bonds in Carboxamides and Sulfonamides.
Zhaodong Li, Qian Wang, Jieping Zhu*; Angew. Chem. Int. Ed. 2018, 57, 13288.
3. Ni-Catalyzed Stereoselective Bis-Carbofunctionalization of Alkyne.
Zhaodong Li,+ Andrés García-Domínguez,+ Cristina Nevado*; Angew. Chem. Int. Ed. 2016, 55, 6938.
4. Pd-Catalyzed Stereoselective Carboperfluoroalkylation of Alkynes.
Zhaodong Li, Andrés García-Domínguez, and Cristina Nevado*; J. Am. Chem. Soc. 2015, 137, 11610.
5. Silver-Catalyzed Radical Fluorination of Alkylboronates in Aqueous Solution
Zhaodong Li, Zhentao Wang, Lin Zhu, Xinqiang Tan, and Chaozhong Li*; J. Am.
Chem. Soc. 2014, 136, 16439.
6. Silver-Catalyzed Radical Aminofluorination of Unactivated Alkenes in Aqueous Media.
Zhaodong Li, Liyan Song, Chaozhong Li*; J. Am. Chem. Soc. 2013, 135, 4640.
7. Transition-Metal-free, Room Temperature Radical Azidofluorination of Unactivated Alkenes in Aqueous Media.
Zhaodong Li, Chengwei Zhang, Lin Zhu, Chao Liu, Chaozhong Li*; Org. Chem. Front. 2014, 1, 100.
8. Stereoselective Carboperfluoroalkylation of Internl Alkynes: Mechanistic Insights.
Zhaodong Li, Estíbaliz Merino, Cristina Nevado*; Topics in catalysis, 2017, 60, 545.
9. Copper‐Catalyzed Cross Coupling of Benzylic Bromides with Arylboronic Acids: Synthesis of Diarylalkanes and Preliminary Antifungal Evaluation Against Magnaporthe Grisea.
Zhu Zhu, Jinggong Liu, Shoucheng Dong, Bolai Chen*, Zhenghui Wang*, Ri‐yuan Tang*, Zhaodong Li*, Asian J. Org. Chem. 2020, 9, 631.
10. Photo‐Mediated Decarboxylative Cross Coupling of Quinoxalin‐2(1H)‐Ones with Aliphatic Carboxylic Acids in Aqueous Solution: Synthesis of Alkylated Quinoxalin‐2(1H)‐Ones and Preliminary Antifungal Evaluation Against Magnaporthe Grisea.
Manyu Shao, Hanbin Liang, Yun‐Lin Liu, Weiwei Qin*, Zhaodong Li*, Asian J. Org. Chem. 2020, 9, 782 .
11. Transtion-metal-free, Intermolecular Azidoheteroarylation of Alkenes: Efficient Access to β-Azidoalkylated Quinoxalinones and Preliminary Antifungal Evaluation Against Magnaporthe Grisea.
Yiming Du, Yihan Chen, Yun-Lin. Liu, Weiwei Qin*, Zhaodong Li*, Synthesis 2020, 52, 2395.
12. Transition Metal-free, Three-component Trifluoromethylative Heteroarylation of Unactivated Alkenes: Efficient Access to β-Trifluoromethylated Quinoxalinones and Preliminary Antifungal Evaluation Against Magnaporthe Grisea.
Zhuoxian Shao, Shaoyi Zhang, Yihan Chen, Yunlin Liu, Ri-Yuan Tang,* Zhaodong Li*, Tetrahedron, 2020, 76, 131199.
13. Fluoroalkylation of allylic alcohols with concomitant aryl migration: efficient access to fluoroalkylated ketones and preliminary antifungal evaluation against Magnaporthe grisea.
Yanhu Zhang, Ziyang Ren , Yunlin Liu, Zhentao Wang,* Zhaodong Li*, Eur. J. Org. Chem. 2020, 5192.
14. Nickel-Catalyzed Reductive Dicarbofunctionalization of Alkene.
Andrés García Domínguez, Zhaodong Li, and Cristina Nevado*; J. Am. Chem. Soc. 2017, 139, 6835.
15. γ-Functionalizations of Amines through Visible-Light-Mediated, Redox-Neutral C−C Bond Cleavage.
Wei Shu, Alexandre Genoux, Zhaodong Li, and Cristina Nevado*; Angew. Chem. Int. Ed. 2017, 56, 10521.
16. Silver-Catalyzed Decarboxylative Radical Azidation of Aliphatic Carboxylic Acids in Aqueous Solution.
Chao Liu, Xiaoqing Wang, Zhaodong Li, Lei Cui, Chaozhong Li*. J. Am. Chem.
Soc. 2015, 137, 9820.
17. Silver-Catalyzed Radical Phosphonofluorination of Unactivated Alkenes in Aqueous Solution.
Chengwei Zhang, Zhaodong Li, Chaozhong Li*; J. Am. Chem. Soc. 2013, 135, 14082.
18. Silver-Catalyzed Decarboxylative Fluorination of Aliphatic Carboxylic Acids in Aqueous Solution.
Feng Yin, Zhentao Wang, Zhaodong Li, Chaozhong Li*; J. Am. Chem. Soc. 2012, 134, 10401.
19. Silver-Catalyzed Decarboxylative Chlorination of Aliphatic Carboxylic Acids.
Zhentao Wang, Zhu Lin, Feng Yin, Zhongquan Su, Zhaodong Li, Chaozhong Li*;
J. Am. Chem. Soc. 2012, 134, 4258.
八、 科研项目
主持基金
1. 国家自然科学基金青年基金:《可见光介导过渡金属催化的烷基自由基的多氟芳基化反应研究》;
2. 广东省自然科学基金面上项目:《多氟芳烃导向农药分子设计与输导机制研究》;
3. 广东省自然科学基金面上项目:《氮杂环丁烷衍生物自由基开环偶联反应研究及其在合成新型农药分子中的应用》。
九、 获奖情况
2016年6月,上海市优秀博士论文;
2015年1月, Novartis Post-doctoral Fellowship